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Év, oldalszám:2016, 26 oldal
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Source: http://www.doksinet Practical Tips on Teaching Biochemistry Rongwu o gwuu Yang g ((Robert obe Young) ou g) Nanjing U University, ve s y, P.R . China 2016/12/06 1. Choose the teaching tool which is best for you Desktop PC or Notebook or iPad Pro Source: http://www.doksinet 2. Each lecture counts, especially first one and last one You have to teach every lecture with passion and take it very seriously Comments from one of my students I love Biochemistry just because of Yang sir. After listening to his first lecture, I cannot wait for next one every week. When I am in bad mood, I just cant help shouting to myself: how much I want to listen to Biochemistry right now� Source: http://www.doksinet How to give the first lecture Give a brief welcome speech Ask one student to talk about how much he or she knows about Biochemistry Play one song called“Biochemistry” Emphasize the class disciplines and introduce the grading policy Invite a senior student who did best in
biochemistry last semester to share the biochemistry-learning experiences Make a brief introduction about the recent biochemistry-related advances made by the Nobel laureates Introduce the molecule or breakthrough of the year related to biochemistry by Science Talk about what Biochemistry is, what biochemistry is about and what is the use of biochemistry Play three videosthe first is a news story about how a mother, a politics professor, treated her kids suffering from cystic fibrosis by self-studying biochemistry; the second one is also a story about how an undergraduate student diagnosed with chordoma from Duke university did his research about cancer in his spare time; the third one is “the inner life of the cell” created by Harvard university Give assignments Biochemistry Biochemistry Biochemistry I wish that I were wiser I feel I’m in way over my head I need a new advisor My courses really shouldnt be Such metabolic misery Biochemistry Biochemistry I wish that I were wiser
Biochemistry Biochemistry Reactions make me shiver They’re in my heart and in my lungs They’re even in my liver I promise I would not complain If I could store them in my brain Biochemistry Biochemistry I wish that I were wiser Biochemistry Biochemistry I’m truly in a panic The mechanisms murder me I should have learned organic For all I have to memorize I ought to win the Nobel Prize. Biochemistry Biochemistry I wish that I were wiser Source: http://www.doksinet A female test-genius from Class 2013 was sharing her biochemistry-learning experiences with her juniors How to give the last lecture ! %$%#%( % ( %( "# ! $ $% %( %% #$% %&# *%$! , ! $%# %$%& %$$#% # ! $%#$%& )"# $ " !% #,!# %"#!% !# % +* !# % " %% # !" % #$% %&# $ !( &
$%& %$ !(!&% !&%% ) #( $" ! (* Source: http://www.doksinet My farewell speech Here let me borrow DNA, proteins and enzymes from biochemistry, to express my best wishes to you! As simple and beautiful as the DNA Double Helix, as helpful as the molecular chaperone, as perfect as the triose phosphate isomerase, being in pursuit of balance and harmony as nucleotide reductase and self-correction just as DNA polymerase! 3. Keep your lecture up to date Examples: a) b) c) d) e) f) Moonlighting proteins Pseudoenzymes CircRNA The fifth base and the sixth base of DNA Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture (Cell 157, 1380– 1392, June 5, 2014 ) A synthetic molecular system capable of mirror-image genetic replication and transcription.(Nat Chem 8(7):698-704,July, 2016) Source: http://www.doksinet 4. Diversify your teaching methods a) b) c)
d) e) f) The bilingual teaching The multimedia teaching Problem-based teaching The elicitation method of teaching Limited Flipped classroom Oral lecture without the help of any other means even ppt slides Well-designed question examples Why dont sickle anemia and β-thalassemia affect fetus? Why can sickle anemia patients or carriers resist malaria? When a woman is pregnant, how will the 2,3-BPG level change in her body Can rats or mice suffer from scurvy? Why is the catalytic efficiency of catalase so high and why is that of RuBP carboxylase just so-so? f) Why can the cystic fibrosis patients or carriers resist cholera g) How can you do to create the trans-membrane proton gradient for E. coli in your intestine h) How can TNT lose your weight? i) What happened if caffeine could inhibit the activity of cGMP phosphodiesterase? j) Why do primates catabolize purine with Uric acid as the end product? a) b) c) d) e) Source: http://www.doksinet 5. Try to make your more interesting a)
Arsenic and death of Wu dalang b) Cholera and death of Tchaikovsky c) Peter Mitchell built the lab in his home to seek evidences in support of the chemiosmotic theory d) German cows cause methane blast in Rasdorf e) Watching scary movies can lose weight f) How did Viagra which was originally developed to cure heart disease become a medicine to cure ED g) How did adefovir which was originally developed to cure AIDS become a medicine to cure hepatitis B h) Introduce the second law by predicting that a building where you are will collapse some day You can express I love you in a biochemical style Isoleucine Leucine pyrrolysine valine glutamate Tyrosine pyrrolysine selenocysteine Source: http://www.doksinet A Poem about how high fidelity of DNA replication is achieved Replicative errors are no big deal, As long as editing is right. Even occurs one mistake, Repairing enzymes will fix it later. 6. Use analogy or comparison, make demonstrations and even play games ☺Comparison
examples a) b) c) d) e) f) RNA and DNA Red muscle and white muscle White adipose tissue and brown adipose tissue Three energy storages: glycogen, fats and proteins Oxidative phosphorylation and photophosphorylation PKA and AMPPK, PFK1 and PFK2CPT1 and CPT2, ACC1 and ACC2, CPS1 and CPS2 g) Various signaling pathways h) Various metabolic pathways i) Bacteria, archaea and eukaryotes Source: http://www.doksinet Analogy examples ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ Titina great man knows when to yield and when not Prion He that touches pitch shall be defiled Cyclin and CDKBehind every active CDK there is a cyclin just like behind every successful man there is a woman F1F0-ATP synthasemolecular cash printerenzymemolecular matchmakersignal peptidemolecular zip code Phospholipid yourself Glycolysis can be likened to cutting in the waist and phosphate pentose pathway can be likened to beheading. The enzyme and its suicidal inhibitorthe farmer and snake in the fable Why do the receptors
of growth factors have to dimerize during actionYou scratch my back and I’ll scratch yours Function of citrate in the cytosol: one stone, four birds Demonstration examples ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ HbS polymerizes in the absence of oxygen How do chaperonin and proteasome work? The difference between single bond and double bond How do hydrophobic interactions form? How do adaptor proteins work? How do hormones act by their receptors? Lock and key model, the induced fit model and three-point attachment model How do pseudoknots form in the RNA? How do positive supercoil of DNA form? How does phosphoglycerate mutase work? Source: http://www.doksinet ☺ ☺ How does HbS polymerize in the absence of oxygen How do chaperonin and proteasome work? Source: http://www.doksinet ☺ ☺ How do hydrophobic interactions form? Lock and key model Source: http://www.doksinet ☺ The induced fit model ☺ Three-point attachment model Source: http://www.doksinet ☺
How do pseudoknots form in the RNA? ☺ How does positive supercoil of DNA form? Source: http://www.doksinet ☺ How does phosphoglycerate mutase work? The reaction catalyzed by phosphoglycerate mutase Source: http://www.doksinet Playing games about the RTK signaling pathway 7. Introduce memorization tricks Examples ☺ Fat-soluble vitamins: coin a new word“DAKE” ☺ Three beta subunits in the different conformation of F1FO-ATPase: “LOT” ☺ Three different sites of ribonucleotide reductase: “CAS” ☺ Three tRNA-binding sites of ribosomes:“APE” ☺ Three antioxidazing vitamins: "ACE" ☺ Ketogenic and glucogenic amino acids: TTTIP ☺ The linkage of bases to ribose or deoxyribose: 911 ☺ Summary of Glycolysis and Krebs Cycle: 1234 ☺ The entryway to glycolysis of pentose or to Krebs cycle of propionate: number game Source: http://www.doksinet 8.Take advantage of modern social media My wechat group named biochemistry paradise My wechat public
account number: iloveBIOCHEM Functions: Spread and popularize the biochemical knowledge, focus and analyze hot issues about biochemistry, exchange biochemistryrelated learning methods or experiences, hold the contest for biochemical knowledge and biochemisty-related short story writing. Make the learning of biochemistry easier and more interesting. Right here, there is no biochemistry crisis, only much fun! Source: http://www.doksinet 9. Combine biochemical theory with practice a) b) c) d) e) f) g) h) i) j) k) Why is eating watermelon skin better for health? Why cant overnight leeks be eaten? How is trans-fat formed and why is it harmful to health? Why is eating raw eggs harmful to health? Why does the bean milk have to be boiled before being drunk? How do aspirin and nitroglycerin work as medicines? Can you read your physical report? Can Q10 and carnitine lose your weight? What is good or bad about the UV? Why cant wild mushrooms randomly picked and eaten? Is there anyone who
cant be infected with HIV Source: http://www.doksinet ☺ My physical report 10. Apply different methods to different parts of biochemistry a) b) c) Structural biochemistry: structure determines properties and function Metabolic biochemistry: biochemical logic Molecular biology: base-paring rules, interaction of proteins and nucleic acids, internal cause and external cause Source: http://www.doksinet The theory of internal cause and external cause a) Protein foldinginternal cause- primary structure, external causemolecular chaperone b) Sorting and targeting of proteinsinternal cause-signal peptides, external cause-signal recognition particle or SRP c) Pre-mRNA splicinginternal cause- splicing signal, external causesnRNPs Base-paring is everywhere All double helices of RNA or DNA DNA replication, transcription, translation, reverse transcription snRNA-dependent Pre-mRNA splicing snoRNA-dependent rRNA processing gRNA-dependent mRNA editing Recognition of bacterial start
codon RNAi, PCR, Southern blotting, Northern blotting, DNA chip, FISH, R-loop technique, genome editing Source: http://www.doksinet 11. Carry out Extra-curricular activities Organize Video-taped Presentation Watch biochemistry-related videos Hold the Contest for biochemical knowledges or biochemical songs Write short biochemical stories Make wine and yogurt by fermentation Celebrate the birthday for the DNA double helix on every 4.25 Promote education about AIDS on each 12.1 A presentation about cytochrome c Source: http://www.doksinet A presentation about pseudoenzymes A documentary film named DNA : secret of photo 51 Source: http://www.doksinet A film named And the band play on Celebrating the 60th birthday of DNA double helix Source: http://www.doksinet Showtime for students to give wrong answers Treating the students who made the best presentation with dinner Source: http://www.doksinet Acknowledgements There are a lot of people and organizations I want to
thank FAOBMB and CSBMB Nanjing University All of my students My family You are welcome to study my structural biochemistry MOOC either on the coursera or on the Chinese university MOOC Source: http://www.doksinet Attending the 11th ceremony of being awarded the students best-loved teachers Attending the 12th ceremony of being awarded the students best-loved teachers Source: http://www.doksinet Thanks a lot!
biochemistry last semester to share the biochemistry-learning experiences Make a brief introduction about the recent biochemistry-related advances made by the Nobel laureates Introduce the molecule or breakthrough of the year related to biochemistry by Science Talk about what Biochemistry is, what biochemistry is about and what is the use of biochemistry Play three videosthe first is a news story about how a mother, a politics professor, treated her kids suffering from cystic fibrosis by self-studying biochemistry; the second one is also a story about how an undergraduate student diagnosed with chordoma from Duke university did his research about cancer in his spare time; the third one is “the inner life of the cell” created by Harvard university Give assignments Biochemistry Biochemistry Biochemistry I wish that I were wiser I feel I’m in way over my head I need a new advisor My courses really shouldnt be Such metabolic misery Biochemistry Biochemistry I wish that I were wiser
Biochemistry Biochemistry Reactions make me shiver They’re in my heart and in my lungs They’re even in my liver I promise I would not complain If I could store them in my brain Biochemistry Biochemistry I wish that I were wiser Biochemistry Biochemistry I’m truly in a panic The mechanisms murder me I should have learned organic For all I have to memorize I ought to win the Nobel Prize. Biochemistry Biochemistry I wish that I were wiser Source: http://www.doksinet A female test-genius from Class 2013 was sharing her biochemistry-learning experiences with her juniors How to give the last lecture ! %$%#%( % ( %( "# ! $ $% %( %% #$% %&# *%$! , ! $%# %$%& %$$#% # ! $%#$%& )"# $ " !% #,!# %"#!% !# % +* !# % " %% # !" % #$% %&# $ !( &
$%& %$ !(!&% !&%% ) #( $" ! (* Source: http://www.doksinet My farewell speech Here let me borrow DNA, proteins and enzymes from biochemistry, to express my best wishes to you! As simple and beautiful as the DNA Double Helix, as helpful as the molecular chaperone, as perfect as the triose phosphate isomerase, being in pursuit of balance and harmony as nucleotide reductase and self-correction just as DNA polymerase! 3. Keep your lecture up to date Examples: a) b) c) d) e) f) Moonlighting proteins Pseudoenzymes CircRNA The fifth base and the sixth base of DNA Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture (Cell 157, 1380– 1392, June 5, 2014 ) A synthetic molecular system capable of mirror-image genetic replication and transcription.(Nat Chem 8(7):698-704,July, 2016) Source: http://www.doksinet 4. Diversify your teaching methods a) b) c)
d) e) f) The bilingual teaching The multimedia teaching Problem-based teaching The elicitation method of teaching Limited Flipped classroom Oral lecture without the help of any other means even ppt slides Well-designed question examples Why dont sickle anemia and β-thalassemia affect fetus? Why can sickle anemia patients or carriers resist malaria? When a woman is pregnant, how will the 2,3-BPG level change in her body Can rats or mice suffer from scurvy? Why is the catalytic efficiency of catalase so high and why is that of RuBP carboxylase just so-so? f) Why can the cystic fibrosis patients or carriers resist cholera g) How can you do to create the trans-membrane proton gradient for E. coli in your intestine h) How can TNT lose your weight? i) What happened if caffeine could inhibit the activity of cGMP phosphodiesterase? j) Why do primates catabolize purine with Uric acid as the end product? a) b) c) d) e) Source: http://www.doksinet 5. Try to make your more interesting a)
Arsenic and death of Wu dalang b) Cholera and death of Tchaikovsky c) Peter Mitchell built the lab in his home to seek evidences in support of the chemiosmotic theory d) German cows cause methane blast in Rasdorf e) Watching scary movies can lose weight f) How did Viagra which was originally developed to cure heart disease become a medicine to cure ED g) How did adefovir which was originally developed to cure AIDS become a medicine to cure hepatitis B h) Introduce the second law by predicting that a building where you are will collapse some day You can express I love you in a biochemical style Isoleucine Leucine pyrrolysine valine glutamate Tyrosine pyrrolysine selenocysteine Source: http://www.doksinet A Poem about how high fidelity of DNA replication is achieved Replicative errors are no big deal, As long as editing is right. Even occurs one mistake, Repairing enzymes will fix it later. 6. Use analogy or comparison, make demonstrations and even play games ☺Comparison
examples a) b) c) d) e) f) RNA and DNA Red muscle and white muscle White adipose tissue and brown adipose tissue Three energy storages: glycogen, fats and proteins Oxidative phosphorylation and photophosphorylation PKA and AMPPK, PFK1 and PFK2CPT1 and CPT2, ACC1 and ACC2, CPS1 and CPS2 g) Various signaling pathways h) Various metabolic pathways i) Bacteria, archaea and eukaryotes Source: http://www.doksinet Analogy examples ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ Titina great man knows when to yield and when not Prion He that touches pitch shall be defiled Cyclin and CDKBehind every active CDK there is a cyclin just like behind every successful man there is a woman F1F0-ATP synthasemolecular cash printerenzymemolecular matchmakersignal peptidemolecular zip code Phospholipid yourself Glycolysis can be likened to cutting in the waist and phosphate pentose pathway can be likened to beheading. The enzyme and its suicidal inhibitorthe farmer and snake in the fable Why do the receptors
of growth factors have to dimerize during actionYou scratch my back and I’ll scratch yours Function of citrate in the cytosol: one stone, four birds Demonstration examples ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ ☺ HbS polymerizes in the absence of oxygen How do chaperonin and proteasome work? The difference between single bond and double bond How do hydrophobic interactions form? How do adaptor proteins work? How do hormones act by their receptors? Lock and key model, the induced fit model and three-point attachment model How do pseudoknots form in the RNA? How do positive supercoil of DNA form? How does phosphoglycerate mutase work? Source: http://www.doksinet ☺ ☺ How does HbS polymerize in the absence of oxygen How do chaperonin and proteasome work? Source: http://www.doksinet ☺ ☺ How do hydrophobic interactions form? Lock and key model Source: http://www.doksinet ☺ The induced fit model ☺ Three-point attachment model Source: http://www.doksinet ☺
How do pseudoknots form in the RNA? ☺ How does positive supercoil of DNA form? Source: http://www.doksinet ☺ How does phosphoglycerate mutase work? The reaction catalyzed by phosphoglycerate mutase Source: http://www.doksinet Playing games about the RTK signaling pathway 7. Introduce memorization tricks Examples ☺ Fat-soluble vitamins: coin a new word“DAKE” ☺ Three beta subunits in the different conformation of F1FO-ATPase: “LOT” ☺ Three different sites of ribonucleotide reductase: “CAS” ☺ Three tRNA-binding sites of ribosomes:“APE” ☺ Three antioxidazing vitamins: "ACE" ☺ Ketogenic and glucogenic amino acids: TTTIP ☺ The linkage of bases to ribose or deoxyribose: 911 ☺ Summary of Glycolysis and Krebs Cycle: 1234 ☺ The entryway to glycolysis of pentose or to Krebs cycle of propionate: number game Source: http://www.doksinet 8.Take advantage of modern social media My wechat group named biochemistry paradise My wechat public
account number: iloveBIOCHEM Functions: Spread and popularize the biochemical knowledge, focus and analyze hot issues about biochemistry, exchange biochemistryrelated learning methods or experiences, hold the contest for biochemical knowledge and biochemisty-related short story writing. Make the learning of biochemistry easier and more interesting. Right here, there is no biochemistry crisis, only much fun! Source: http://www.doksinet 9. Combine biochemical theory with practice a) b) c) d) e) f) g) h) i) j) k) Why is eating watermelon skin better for health? Why cant overnight leeks be eaten? How is trans-fat formed and why is it harmful to health? Why is eating raw eggs harmful to health? Why does the bean milk have to be boiled before being drunk? How do aspirin and nitroglycerin work as medicines? Can you read your physical report? Can Q10 and carnitine lose your weight? What is good or bad about the UV? Why cant wild mushrooms randomly picked and eaten? Is there anyone who
cant be infected with HIV Source: http://www.doksinet ☺ My physical report 10. Apply different methods to different parts of biochemistry a) b) c) Structural biochemistry: structure determines properties and function Metabolic biochemistry: biochemical logic Molecular biology: base-paring rules, interaction of proteins and nucleic acids, internal cause and external cause Source: http://www.doksinet The theory of internal cause and external cause a) Protein foldinginternal cause- primary structure, external causemolecular chaperone b) Sorting and targeting of proteinsinternal cause-signal peptides, external cause-signal recognition particle or SRP c) Pre-mRNA splicinginternal cause- splicing signal, external causesnRNPs Base-paring is everywhere All double helices of RNA or DNA DNA replication, transcription, translation, reverse transcription snRNA-dependent Pre-mRNA splicing snoRNA-dependent rRNA processing gRNA-dependent mRNA editing Recognition of bacterial start
codon RNAi, PCR, Southern blotting, Northern blotting, DNA chip, FISH, R-loop technique, genome editing Source: http://www.doksinet 11. Carry out Extra-curricular activities Organize Video-taped Presentation Watch biochemistry-related videos Hold the Contest for biochemical knowledges or biochemical songs Write short biochemical stories Make wine and yogurt by fermentation Celebrate the birthday for the DNA double helix on every 4.25 Promote education about AIDS on each 12.1 A presentation about cytochrome c Source: http://www.doksinet A presentation about pseudoenzymes A documentary film named DNA : secret of photo 51 Source: http://www.doksinet A film named And the band play on Celebrating the 60th birthday of DNA double helix Source: http://www.doksinet Showtime for students to give wrong answers Treating the students who made the best presentation with dinner Source: http://www.doksinet Acknowledgements There are a lot of people and organizations I want to
thank FAOBMB and CSBMB Nanjing University All of my students My family You are welcome to study my structural biochemistry MOOC either on the coursera or on the Chinese university MOOC Source: http://www.doksinet Attending the 11th ceremony of being awarded the students best-loved teachers Attending the 12th ceremony of being awarded the students best-loved teachers Source: http://www.doksinet Thanks a lot!
