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BLEMISH AGE DEFENSE As effective as Tretinoin, the leading prescription drug for signs of aging, with significantly better results in three key attributes O B JE CTI V E RES ULTS To evaluate the efficacy of SkinCeuticals Blemish + Age Blemish + Age Defense was statistically better than Tretinoin Defense (OTC serum containing 1.5% salicylic acid, 35% at improving skin tone (weeks 1, 4, and 8) and blotchiness glycolic acid, 2% dioic acid, and 0.3% capryloyl salicylic acid) (weeks 4 and 8) and reducing total lesions (weeks 1 and 8). vs. Tretinoin (0025% prescription drug) for the treatment of Blemish + Age Defense and Tretinoin show equal statistically signs of aging in subjects experiencing adult acne. significant improvement in all other signs of aging and acne. M E THO D O LO GY Both products were well tolerated. No adverse events occurred A single-center, split-face, double-blind, 8-week clinical trial of 30 subjects was conducted by a board-certified dermatologist.

Blemish + Age Defense® 0.025% Tretinoin Evaluation methods included nine-scale clinical grading for facial attributes, counting of acne lesions, subjective and objective evaluation of tolerance, and consumer * Statistically significant improvement + Statistically better than 0.025% Tretinoin self-assessment. SKIN TONE (CLARITY) Primary Inclusion Criteria S K IN TO N E ( C LARITY ) • 35+ years old • Mild to moderate acne (at least 4 inflammatory lesions and 7 non-inflammatory lesions on each side of the face, no cysts) -10 -10 -20 -30 -40 -50 -70 • Available upon request TOTAL LESSIONS Washout period: 7 days -20 -30 -40 -50 -60 Day 2 BLOTC H IN ES S 0 PROTOCOL Week 1 Week 4 Week 8 -70 BLOTCHINESS 0 -10daily, subjects applied Blemish + Age Defense to one Twice sunscreen (Ultimate UV Defense SPF 30), and moisturizer -40 (Daily Moisture) to effectively evaluate the efficacy of the test -50 products alone. -60 -1 Average % Reduction regimen was limited to a

basic cleanser (Simply Clean), -30 -10 Average % Reduction Average % Reduction side-20 of the face and Tretinoin to the other side. The supporting Day 2 0 -60 Exclusion Criteria -70 0 Average % Reduction Secondary Inclusion Criteria Average % Reduction • Males and females with mild to moderate signs of aging -20 -30 -40 -50 -60 Week 1 Week 4 Week 8 -70 -2 -3 -4 -5 -6 Day 2 Week 1 Week 4 Week 8 PDF compression, OCR, web optimization using a watermarked evaluation copy of CVISION PDFCompressor -7 DULLNESS ROUGHNESS TOTAL LESSIONS DULLNESS -20 -30 -30 -40 -40 -50 -50 -60 -60 -70 -70 Day 2 Day 2 -10-10 -10 -10 -20 -20 -30 -30 -40 -40 -50 -50 -60 -60 -70 -70 D -20-20 -30-30 -40-40 -50-50 -60-60 D U LL NE SS Week 1 Week 1 Week 4 Week 4 Week 8 Week 8 -70 -70 Week 1 1 Week Week 4 4 Week Week 8 8 Week TOTAL LESSIONS C O N C LUS IO N Blemish + Age Defense is shown to be statistically better 0 than Tretinoin in improving skin

tone (weeks 1, 4, and 8) and -10 -10 Average % Reduction blotchiness (weeks 4 and 8) and in reducing total lesions -20 -20 (weeks 1 and 8). Blemish + Age Defense is equally as effective -30 as Tretinoin in improving all other signs of aging and acne. -40 At no-40 point during the 8 weeks did Tretinoin statistically -50 -50 outperform Blemish + Age Defense. -60 -70 -30 Day 2 Week 1 Week 4 -70 Week 8 Day 2 Week 1 Week 4 Week 8 CLOGGED PORES -10 -10 Average % Reduction 0 -20 -30 -40 -50 -60 -20 -30 -40 -50 -60 Day 2 C LO GGE D P O RE S Week 1 Week 4 Week 8 -70 Day 2 Week 1 Week 4 Week 8 CLOGGED PORES 0 Average % Reduction -10 -20 -30 -40 -50 -60 -70 Day 2 Week 1 Week 4 -2 -3 -4 -5 -6 FINE LINES 0 -70 -1 -60 FI NE LI NE S Average % Reduction DayDay 2 2 DULLNESS 0 Average % Reduction 0 Average % Reduction -20 0 Average % Reduction -10 0 Average % Reduction -10 0 Average % Reduction 0 TOTAL LES IO N S Average %

Reduction 0 Average % Reduction Average % Reduction RO U GH NE SS Week 8 PDF compression, OCR, web optimization using a watermarked evaluation copy of CVISION PDFCompressor -7